Effects of intrahippocampal injections with methylscopolamine and neostigmine upon exploratory behaviour in two inbred mouse strains

✍ Scribed by J. Abeelen; L. Gilissen; Th. Hanssen; A. Lenders

• Book ID: 104769632
• Publisher: Springer
• Year: 1972
• Tongue: English
• Weight: 306 KB
• Volume: 24
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00423437

✦ Synopsis

After stereotaxieally injecting male mice of the inbred strains C57BL/6 and DBA/2 with two doses of methylscopolamine or with two doses of neostigmine into the left dorsal hippocampus, the frequencies of the exploratory acts rearing, leaning, and sniffing carried out in a novel environment were recorded. At the lower dose-level, the antieholinergic drug tended to augment exploration in strain DBA and to reduce it in strain C57BL; the two doses of anticholinesterase diminished the scores in both genotypes. From these data it is concluded that the hippoeampus contains a eholinergie mechanism which regulates exploratory behaviour and which is genetically controlled.