Effects of intermittent haloperidol treatment on dopamine receptor sensitivity in guinea pigs

✍ Scribed by William C. Koller

• Book ID: 104771613
• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 301 KB
• Volume: 84
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00432034

✦ Synopsis

Intermittent haloperidol treatment in guinea pigs caused an increase in the behavioral response to apomorphine and an increase oin 3H-spiroperidol binding in the striatum to the same degree as continual haloperidol treatment. These results do not support the claim that drug holidays can reduce the incidence of tardive dyskinesia.