Sensitivity to insulin in vivo was studied in 8 normal weight C-peptide negative Type 1 (insulin-dependent) diabetic patients (age 23 +/- 1 years, diabetes duration 6 +/- 2 years), and in 8 age, weight and sex matched healthy subjects, using the euglycaemic clamp and 3-3H-glucose tracer technique. P
Effects of insulin-sensitising agents in mice with hepatic insulin resistance
β Scribed by S. E. Cohen; Y.-H. Tseng; M. D. Michael; C. R. Kahn
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 275 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0012-186X
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## Abstract ## Background Hepatic insulin gene therapy (HIGT) produces nearβnormal glycemia in diabetic rats. Hepatic insulin production is expected to stimulate glycogen storage. However, the effect of HIGT on hepatic glycogen metabolism __in vivo__ is unknown. ## Methods After administration o
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