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Effects of inorganic and organic lead compounds on chromosomal length in human lymphocytes

โœ Scribed by Ole Andersen; Philippe Grandjean

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
303 KB
Volume
1
Category
Article
ISSN
0268-2605

No coin nor oath required. For personal study only.

โœฆ Synopsis

Receited 3 Junuury 1986 Acctepted 23 M a ) I986

In vitro exposure of human lymphocyte cultures to spindle inhibitors reduce the average chromosome length'". In this report chromosome length measurements were used for indirect but quantitative evaluation of the effects of inorganic and organic lead compounds on spindle function. The data indicate that organic compounds are much more powerful spindle inhibitors than inorganic lead compounds, almost as potent as colchicine. Occupational exposure to organic lead compounds may result in partial spindle inhibition, leading to a high probability of nondisjunction.

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