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Effects of induction of R- and S-warfarin and metabolite concentrations in rat plasma

✍ Scribed by Michael J. Fasco; Mark J. Cashin

Book ID
113205473
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
736 KB
Volume
56
Category
Article
ISSN
0041-008X

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## Abstract Several forms of cytochrome P‐450 (CYP) metabolize __R,S__‐warfarin in a regio‐ and enantioselective manner, therefore __R,S__‐warfarin can be recognized as a metabolic probe for a number of CYP isoforms. We have applied a warfarin model __in vivo__ in order to estimate the inhibitory p