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Effects of indomethacin on glycosaminoglycan metabolism in the development of experimental osteoarthritis in rabbits

✍ Scribed by T. Videman; I. Eronen; C. Friman; K. Ahtiala; M.J. Mattila

Book ID: 115775665
Publisher: Elsevier Science
Year: 1981
Tongue: English
Weight: 527 KB
Volume: 30
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(81)90234-3

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## Abstract The interaction between indomethacin (IND) and methotrexate (MTX) was investigated in rabbits. The study was designed so as to evaluate the effect of IND (1 mg h^−1^) during a continuous MTX infusion (1·2 mg kg^−1^) over 240 min. IND was injected i.v. at hourly intervals after a steady