Effects of immobilization onto aluminum hydroxide particles on the thermally induced conformational behavior of three model proteins

Influence of protein conformation and ad

Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine

✍ Amber L. Clausi; Andrea Morin; John F. Carpenter; Theodore W. Randolph 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB

The mechanism(s) of the enhancement of the immune response by addition of aluminum salt adjuvants to parenterally administered protein-based vaccines is still the subject of debate. It has been hypothesized, however, that destabilization of the antigen structure on the surface of the adjuvant may be