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Effects of IL-23 and IL-27 on osteoblasts and osteoclasts: inhibitory effects on osteoclast differentiation

โœ Scribed by Sadahiro Kamiya; Chika Nakamura; Takeshi Fukawa; Katsuhiro Ono; Toshiyuki Ohwaki; Takayuki Yoshimoto; Seiki Wada

Publisher
Springer
Year
2007
Tongue
English
Weight
325 KB
Volume
25
Category
Article
ISSN
0914-8779

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## Abstract Interleukin 1 (ILโ€1) is a proinflammatory cytokine upregulated in conditions such as rheumatoid arthritis and periodontal disease. Both isoforms, ILโ€1ฮฑ and ILโ€1ฮฒ, have been shown to activate osteoclasts (OCs), the cells responsible for resorbing bone. Inflammatory conditions are also ch