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Effects of hyperthermia and iodine-131 labeled anticarcinoembryonic antigen monoclonal antibody on human tumor xenografts in nude mice

✍ Scribed by Bharat B. Mittal; A. Michael Zimmer; Vythialingam Sathiaseelan; Steven T. Rosen; James A. Radosevich; Alfred W. Rademaker; A. Saini; M. C. Pierce; Denise I. Webber; Stewart M. Spies

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
698 KB
Volume
70
Category
Article
ISSN
0008-543X

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✦ Synopsis

Background. Many studies have demonstrated synergistic interaction between hyperthermia and radiation. This study was undertaken to determine whether hyperthermia could enhance the effect of radioimmunotherapy (RIT) in the treatment of human colon adenocarcinoma xenografts in nude mice.

The experiments were conducted in two parts. During the first part of the study, preliminary information was obtained regarding the effect of various temperatures (41°C, 42"C, and 43OC for 45 minutes) and iodine-131-labeled anticarcinoembryonic antigen (CEA) monoclonal antibodies (RMoAb) with administered activity ranging from 130 f 19 pCi to 546 k 19 pCi on tumor regrowth delay (TRD) and volume doubling time. This information was used in Part 2 of the study, which included four groups of mice: (1) a control group, (2) a group treated with hyperthermia, (3) a group treated with RMoAb, and (4) a group treated with a combination of RMoAb and hyperthermia.

Results. Maximum and significantly increased TRD was observed in the group treated with RMoAb and hyperthermia (slope, 0.057) compared with the control Methods.

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