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Effects of Hydroxyurea and 1-β-D-Arabinofuranosyl-cytosine on Deoxyribonucleotide Pools in Mouse Embryo Cells

✍ Scribed by Lambert Skoog; Bo NordenskjÖLD

Book ID: 115112620
Publisher: John Wiley and Sons
Year: 1971
Tongue: English
Weight: 780 KB
Volume: 19
Category: Article
ISSN: 1432-1327
DOI: 10.1111/j.1432-1033.1971.tb01290.x

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## Abstract The cytotoxic effect of 1‐β‐D‐arabinofuranosyl cytosine (araC) depends on the intracellular phosphorylation into its active compound araCTP, on the degree of degradation of araCTP and on the incorporation of araCTP into DNA. Deoxycytidine triphosphate (dCTP) inhibits the phosphorylation