Effects of aging and degeneration on the
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Christopher J. Massey; Corrinus C. van Donkelaar; Edward Vresilovic; Antonios Za
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Article
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2011
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Elsevier Science
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English
⚖ 513 KB
## Abstract A significant biochemical change that takes place in intervertebral disc degeneration is the loss of proteoglycans in the nucleus pulposus. Proteoglycans attract fluid, which works to reduce mechanical stresses in the solid matrix of the nucleus and provide a hydrostatic pressure to the