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Effects of Human Cytochrome b5on CYP3A4 Activity and Stabilityin Vivo

โœ Scribed by Mike W. Voice; Yan Zhang; C.Roland Wolf; Brian Burchell; Thomas Friedberg

Book ID
115567611
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
204 KB
Volume
366
Category
Article
ISSN
0003-9861

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In Vitro/in Vivo scaling of alprazolam m
In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans
โœ Noriko Hirota; Kiyomi Ito; Takafumi Iwatsubo; Carol E. Green; Charles A. Tyson; ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 243 KB ๐Ÿ‘ 1 views

We attempted to predict the in vivo metabolic clearance of alprazolam from in vitro metabolic studies using human liver microsomes and human CYP recombinants. Good correlations were observed between the intrinsic clearance (CL int ) for 4-hydroxylation and CYP3A4 content and between the CL int for a