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Effects of high dose raloxifene in selected patients with advanced breast carcinoma

✍ Scribed by William Gradishar; Joan Glusman; Yili Lu; Charles Vogel; Fredric J. Cohen; George W. Sledge Jr.

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
78 KB
Volume
88
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND. An earlier trial of raloxifene, conducted in women with metastatic breast carcinoma who initially had responded to tamoxifen and subsequently developed disease progression, suggested no antitumor activity for raloxifene in tamoxifen-refractory disease. However, preclinical studies and preliminary clinical data in healthy women suggest that raloxifene antagonizes growth of estrogendependent neoplasia.

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