Effects of heparin, dextran sulfate, and synthetic (1→6)-α-d-mannopyranan sulfate and acidic fibroblast growth factor on 3T3-L1 fibroblasts

Acidic and basic fibroblast growth facto

Acidic and basic fibroblast growth factor bind with differing affinity to the same heparan sulfate proteoglycan on BALB/c 3T3 cells: Implications for potentiation of growth factor action by heparin

✍ Kathryn J. Brown; Ian A. Hendry; Christopher R. Parish 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 806 KB

Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-1301 and play an important role in the interaction of FGF with the FGF receptor (FGFR). In this study, several aspects of