๐”– Bobbio Scriptorium
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Effects of helium group gases and nitrous oxide on hela cells

โœ Scribed by J. H. Bruemmer; B. B. Brunetti; H. R. Schreiner

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
539 KB
Volume
69
Category
Article
ISSN
0021-9541

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โœฆ Synopsis

The helium group gases and nitrous oxide at superatmospheric pressures depress multiplication of HeLa cells in monolayer cultures. The effectiveness of these gases in eliciting the pressure-dependent response follows the order NzO, Xe > Kr > Ar > > Ne and He. The response correlates with lipid solubility of the gases. Depression of growth by 4.2 atm Xe is reversible after exposure for one and two days. Cultures exposed to 7.2 atm Xe show irreversible damage including cytoplasmic vacuolization.

Cell attachment is strongly inhibited by Xe; 36% of the cell inoculum were not attached after 24 hours.

Affinity for hydrophobic sites in the cell is suggested as determining the order of effectiveness of the gases in evoking the response.

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