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Effects of H2-receptor antagonists on dapsone-induced methaemoglobinaemia in rats

✍ Scribed by Wilson Roberto Malfará; Carolina Paula Pereira; Antonio Cardozo Dos Santos; Regina Helena Costa Queiroz

Book ID
118771085
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
92 KB
Volume
45
Category
Article
ISSN
1043-6618

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Oxmetidine, a new and more potent analogue of the H2 receptor antagonist, cimetidine, was recently withdrawn from clinical trials because of associated hepatotoxicity. We investigated the potential hepatotoxicity of the drug in vitro and in vivo in the rat. In addition, we investigated, in in vitro