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Effects of glutathione on chromium‐induced DNA. Crosslinking and DNA polymerase arrest

✍ Scribed by Travis O'Brien; Jian Xu; Steven R. Patierno

Book ID
110366991
Publisher
Springer
Year
2001
Tongue
English
Weight
295 KB
Volume
222
Category
Article
ISSN
0300-8177

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We have previously shown that trivalent chromium, and hexavalent chromium in the presence of one of its primary in vivo reductants, ascorbate, can bind to DNA and form interstrand crosslinks capable of obstructing replication. This effect was demonstrated in vitro by using Sequenase Version 2.0 T7 D