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Effects of glucosinolate breakdown products on the hepatic biotransformation system in male rats

✍ Scribed by Ozierenski, B. ;Plass, R. ;Lewerenz, H.-J.

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
504 KB
Volume
37
Category
Article
ISSN
0027-769X

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✦ Synopsis

Abstract

The effects of 5‐vinyloxazolidine‐2‐thione (VOT), 1‐cyano‐3‐butene (CYB) and various isothiocyanates on parameters of hepatic phase I and phase II biotransformation were investigated in male rats after oral treatment for 3 consecutive days. The compounds with the exception of CYB caused increases in liver weight and glutathion S‐transferase activity. Cytochrome P‐450 level and monooxygenase activities were decreased by the isothiocyanates and CYB. Administration of VOT resulted in contrasting response of monooxygenases: reduced aminopyrine N‐demethylation and enhanced aniline hydroxylation. Possible mechanisms were discussed.

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