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Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice

✍ Scribed by Matthew L Kelso; Stephen W Scheff; James R Pauly; Charles D Loftin


Book ID
115006054
Publisher
BioMed Central
Year
2009
Tongue
English
Weight
388 KB
Volume
10
Category
Article
ISSN
1471-2202

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## Abstract Increasing evidence suggests a role for cyclooxygenase‐2 (COX‐2) in traumatic brain injury (TBI). In the present study, the role of COX‐2 in TBI was investigated using COX‐2 gene‐disrupted (COX‐2 null) mice and wild‐type (WT) controls that were subjected to the controlled cortical impac