Recent work demonstrated that the heavy metal ion Cd2+ increases the transport of p-aminohippuric acid (PAH) across the basolateral membrane of microdissected non-perfused rabbit kidney S2 proximal tubule segments. Usually, such ions induce damage of various renal transport systems, therefore the ef
Effects of gender on the pharmacokinetics of drugs secreted by the renal organic anions transport systems in the rat
β Scribed by Jorgelina A. Cerrutti; Nora B. Quaglia; Anabel Brandoni; Adriana M. Torres
- Book ID
- 118771053
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 182 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1043-6618
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The renal secretion of carbenicillin (CBPC) was studied in rats. The results obtained in the in vivo study indicated very poor renal secretion of CBPC in rats, which was entirely different from those observed in humans and rabbits. In humans and rabbits, significant and stereoselective renal secreti
Stereoselectivity in the renal secretion of carbenicillin (CBPC) was studied in rabbits. Significant renal secretion of CBPC was observed in vivo, with the secretion of the S-epimer being greater than that of the R-epimer. Stereoselective transport of CBPC was further studied in vitro using basolate