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Effects of GBR 12909, WIN 35,428 and indatraline on cocaine self-administration and cocaine seeking in rats

โœ Scribed by Susan Schenk

Publisher
Springer
Year
2002
Tongue
English
Weight
136 KB
Volume
160
Category
Article
ISSN
0033-3158

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Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans
โœ Victor L. Villemagne; Richard B. Rothman; Fuji Yokoi; Kenner C. Rice; Dorota Mat ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 122 KB ๐Ÿ‘ 1 views

GBR12909 (GBR) is a high-affinity, selective, and long-acting inhibitor of dopamine (DA) uptake that produces a persistent and noncompetitive blockade of DA transporters and substantially reduces cocaine-induced increases in extracellular DA in the nucleus accumbens of rats. Prior studies showed tha