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Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes

✍ Scribed by Sture Liljequist; Jörgen Engel

Publisher
Springer
Year
1982
Tongue
English
Weight
564 KB
Volume
78
Category
Article
ISSN
0033-3158

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✦ Synopsis

The interaction between ,ethanol and various GABAergic drugs (muscimol, bicuculline, picrotoxin) with regard to their effects on locomotor activity, drug-induced sleep, body temperature, and convulsions was studied. It was demonstrated that the GABA receptor agonist muscimol potentiated the sedative properties of ethanol, while the opposite effect, a reduction of ethanol-produced sedation, was seen upon administration of the GABA receptor blocking agent picrotoxin. Consequently, the results from the present series of experiments indicate that ethanol enhances central GABAergic activity.

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