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Effects of Furanocoumarin Derivatives in Grapefruit Juice on Nifedipine Pharmacokinetics in Rats

โœ Scribed by Kiminori Mohri; Yoshihiro Uesawa

Book ID
110296738
Publisher
Springer US
Year
2001
Tongue
English
Weight
150 KB
Volume
18
Category
Article
ISSN
0724-8741

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โœ John S. Grundy; Lise A. Eliot; Ken M. Kulmatycki; Robert T. Foster ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 157 KB ๐Ÿ‘ 2 views

Previous studies with rats indicate that nifedipine undergoes both hepatic and extrahepatic presystemic metabolism after peroral (po) administration, and that its bioavailability is increased and absorption delayed by concomitant administration of grapefruit juice concentrate (GJC). Hence, the effec