Effects of FMRFamide on the intact and isolated circulatory system of the pinto abalone,Haliotis kamtschatkana

✍ Scribed by Krajniak, K. G. ;Bourne, G. B.

• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 312 KB
• Volume: 241
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1402410315

✦ Synopsis

The in vivo and in vitro effects of the molluscan tetrapeptide, FMRFamide, were examined on the circulatory system of the pinto abalone, Haliotis kamtschatkana. When perfused through isolated hearts, FMRFamide caused a dose-dependent increase in heart rate. Injected into the circulation of intact, unrestrained animals, the peptide initially enhanced the rate of beating, augmented the aortic diastolic and pulse pressures, and raised the arteriovenous (AV) pressure difference; but at higher doses, this initial enhancement was followed by a decrease in aortic blood pressure, an increase in efferent ctenidial pressure, and a substantially reduced heart rate. Therefore, FMRFamide could have a role in controlling the circulation of H. kamtschatkana.