The aggregation of amyloid P peptide (AP) into its fibrillar, cross P-pleated configuration is generally viewed as a critical event in the pathophysiology of Alzheimer's disease (AD). A diverse group of molecules, the AP binding proteins, has been evaluated for their effects on this process. However
✦ LIBER ✦
Effects of Fatty Acids and Phospholipids on Amyloid-β (Aβ) Peptide Aggregation
✍ Scribed by Kumar, Amit; Rice, Rebakah; Lidell, Shiela A.; Paslay, Lea C.; Morgan, Sarah; Rangachari, Vijay
- Book ID
- 122114462
- Publisher
- Biophysical Society
- Year
- 2010
- Tongue
- English
- Weight
- 40 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0006-3495
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DNA could readily associate with the aggregated forms of the -amyloid peptides (1-40) and (25-35), giving rise to a shift in the electrophoretic mobility of DNA. As a result, DNA was retained at the top of a 1% agarose gel. In contrast, the electrophoretic mobility of DNA was little influenced by