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Effects of farnesol on the thermotropic behavior of dimyristoylphosphatidylcholine

✍ Scribed by Olga P. Bondar; George Melnykovych; Elizabeth S. Rowe

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 297 KB
Volume: 74
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(94)90115-5

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✦ Synopsis

Differential scanning calorimetry (DSC) and DPH fluorescence anisotropy have been used to investigate the effects of trans-trans farnesol on the physical properties of model membranes and extracted cell lipids. Farnesol was shown to have a significant effect on the gel to liquid-crystal phase transition temperature, the enthalpy of the transition and the transition co-operativity for extruded vesicles of dimyristoylphosphatidylcholine (DMPC). The phase transition of DMPC vesicles was eliminated at 25 tool% faruesol. Farnesol decreased the fluorescence anisotropy of the lipids extracted from human leukemia line CEM-C1 cells.

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