Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor
✍ Scribed by Ferri, Catharine C. ;Moore, Fraser A. ;Bisby, Mark A.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 357 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-3034
No coin nor oath required. For personal study only.
✦ Synopsis
When motoneuron axons in periph-{ standard error of the mean 3%, n Å 11 vs. 67 { 5%, eral nerves are injured, the expression of the p75 lown Å 11 in CD-1 mice and 68.0 { 4%, n Å 6 in balb/ affinity neurotrophin receptor (p75) increases in their c mice), and significantly more regenerating axons cell bodies and axons, as well as in the Schwann cells were present in the distal facial nerve. After axotomy undergoing Wallerian degeneration in the distal exon postnatal day 1, there was almost total loss of motocised nerve segment. To understand the role of p75 in neuron profiles in the lateral facial nucleus in p75 the events following nerve injury, we have examined (///) mice (1.7 { 0.3% remained, n Å 5), while the survival and regeneration of motoneurons in mice significantly more survived in p75 (0/0) mice (17 lacking the p75 receptor. In adult p75 (0/0) mice, { 2.5%, n Å 6). We conclude that expression of p75 in functional recovery of whiskers movement following motoneurons or Schwann cells following facial nerve a facial nerve crush occurred slightly earlier than in injury is not necessary for motoneuron survival or p75 (///) mice, and some recovery of function over prompt regeneration of their axons; rather, p75 may a 25-day interval following a nerve cut occurred more increase their risk of dying. ᭧ 1998 John Wiley & Sons, frequently in p75 (0/0) mice. Motoneuron profile Inc. J Neurobiol 34: 1-9, 1998 numbers were slightly reduced in p75 (0/0) mice, Keywords: facial motoneurons; axotomy; p75 low-afand there were correspondingly fewer axons in the finity neurotrophin receptor; Schwann cells; regenerfacial nerve. At 25 days following axotomy, profile ation survival in the adult p75 (0/0) mice was significantly