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Effects of excitatory and inhibitory amino acids on phasic respiratory neurons

✍ Scribed by J. R. Toleikis; L. Wang; L. L. Boyarsky

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Volume
4
Category
Article
ISSN
0360-4012

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✦ Synopsis

The responsiveness of phasically active brainstem respiratory neurons t o several amino acids was investigated in cats under Dial anesthesia. Four-barreled microelectrodes were used t o extrude iontophoretically the putative neurotransmitters L-glutamate, L-aspartate, glycine, and gamma-aniinobutyric acid (GABA) L-glutamate and L-aspartate caused increased activity when applied to either inspiratory or expiratory neurons and appeared to be equal in efficacy. Likewise, GABA and glycine depressed ongoing phasic neural activity of both inspiratory and expiratory units. In this case, however, the dosage of GABA required to produce a given depression was significantly less than the required dosage of glycine. These findings support the hypothesis that L-glutamate and/or Laspartate may act as excitatory neurotransmitter agents at the synapses of brainstem respiratory neurons and conversely, GABA may act as the natural inhibitory neurotransmitter.

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