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Effects of etomidate on steroid biosynthesis in subcellular fractions of bovine adrenals

✍ Scribed by H. Vanden Bossche; G. Willemsens; W. Cools; D. Bellens

Book ID
115777356
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
871 KB
Volume
33
Category
Article
ISSN
0006-2952

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The narcotic agent etomidate and the antimycotic drug ketoconazole are known to block steroid biosynthesis in man. To study the different effects of these imidazole derivatives on human adrenal steroid biosynthesis we incubated slices of human adrenal glands with 3H-labeled precursors and increasing