Effects of ethanol ingestion and urinary acidity on the metabolism of triethylamine in man

✍ Scribed by B. Åkesson; S. Skerfving

• Publisher: Springer-Verlag
• Year: 1990
• Tongue: English
• Weight: 439 KB
• Volume: 62
• Category: Article
• ISSN: 0340-0131
• DOI: 10.1007/bf00397854

✦ Synopsis

In four volunteers exposed to triethylamine (TEA) by inhalation ( 20 mg/m 3 , 8 h), the nonrenal clearance of TEA into triethylamine-N-oxide (TEAO) was inhibited by 15 to 30 % by intake of ethanol (blood serum level in average 25 mmol/l). Ethanol intake caused a decrease of plasma levels of TEA and TEAO, and of the fractional formation of TEAO This may partly be due to a second effect of ethanol; it caused a slight decrease of urinary p H, which led to an increase of the urinary TEA excretion rate, with a possible withdrawal of TEA from oxygenation Indeed, this effect was efficiently counteracted by intake of sodium bicarbonate, which caused a decrease of renal clearance of TEA, and increases of plasma levels of TEA and TEAO, and of the fractional formation of TEAO A change of urinary p H by about two units caused a change of renal clearance of TEA by a factor of three and of the oxygenation by two The renal clearance of TEAO was not affected by urinary p H.