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Effects of ethanol and Δ9-tetrahydrocannabinol on phencyclidine disposition in dogs

✍ Scribed by Paul J. Godley; Emory S. Moore; James R. Woodworth; Jerry Fineg

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
513 KB
Volume
12
Category
Article
ISSN
0142-2782

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✦ Synopsis

A three-way crossover study was performed to determine the influence of A'-tetrahydrocannabinol (THC) and ethanol (EtOH) separately upon phencyclidine (PCP) disposition in dogs. Seven dogs were given three single dose treatments: 1.5 mg PCP kg-' i.v., 1.5mg PCP kg-' i.v. with 0.4mgkg-' THC i.v., and 1.5mg PCP kg-' i.v. with 1.25g EtOH kg-' i.v. PCP was measured in plasma samples collected for 24 h after administration of each treatment, with several pharmacokinetic parameters calculated from the plasma concentration vs time data. The PCP serum C1, values were significantly lower when administered with THC than when administered alone, with no significant change in Vs or tOh. EtOH did not induce significant changes in any PCP pharmacokinetic parameter, although mean C1, and Va were increased. These results confirm the observed THC inhibition of PCP metabolism, and suggest that the enhanced pharmacologic action of PCP by THC may result from higher serum PCP concentrations. These results further suggest that enhanced PCP actions by acute EtOH administration may result from increased PCP distribution to the CNS.

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