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Effects of estrogen on leptin gene promoter activation in MCF-7 breast cancer and JEG-3 choriocarcinoma cells: selective regulation via estrogen receptors α and β

✍ Scribed by Jennifer S O'Neil; Matthew E Burow; Amy E Green; John A McLachlan; Michael C Henson

Book ID
117462740
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
171 KB
Volume
176
Category
Article
ISSN
0303-7207

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## Abstract To further explore the role of Sp1 and Sp3 in the estrogen regulated TFF1 gene transcription, chromatin immunoprecipitation (ChIP) assay was used to determine the association of estrogen receptor α (ERα), Sp1 and Sp3 with the endogenous trefoil factor 1 (TFF1) gene promoter in MCF‐7 bre