Effects of estradiol and progesterone on lactation

✍ Scribed by Masson, Georges M. C.

• Publisher: John Wiley and Sons
• Year: 1948
• Tongue: English
• Weight: 602 KB
• Volume: 102
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1091020408

✦ Synopsis

tlehydro-iso-aiiilrosteroiie aiid pregnant mare's serum (PJIS) inhibit lactation in aornial but not in ovaricetomized rats (Rarsantiiii and Massoii, '47). Since these hormoiics are stroiigly luteotropie, it has beeu suggestcd that some re-liitionshil> exists between the pregnancy type corpora lutea fornied under the influcnce of the treatment and the inliil~ition of lactation (RIasson arid Barsantini, '48). Many obscrvatioiis ( reviewed by Rarsantiiii aiid Massoii, '47) liare clearly demonstrated that the active corpus lutcuni pi*events the onset of lactation. Siiicc corpora lutea are normally present during lactation, it may be assumed that tlie latter are pliysiologicallp cliff'ercnt from those produced by the steroids o r by PXIS or those prescn t during prcgiiaiicy.

Although progesterone is secreted by large corpora lutea as indicated by the formation of deciduomata (Fluhmann and Laqueur, '42) it caiinot he considered rcsponsible for inhibition of Iactation since large doses do not iriflueiice lactation iii noriiial rats (Folley a i d lion, '38 ; Rawsantirii aiid Masson, '47). Recent Iiistologic studies of tlie uterus from lactating l This moik was supported by :I p a n t froin the National J3rsm~11 Council of