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Effects of estazolam and triazolam on transient insomnia associated with phase-shifted sleep

✍ Scribed by P. K. Schweitzer; G. Koshorek; M. J. Muehlbach; D. D. Morris; T. Roehrs; J. K. Walsh; T. Roth

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 657 KB
Volume: 6
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470060204

No coin nor oath required. For personal study only.

✦ Synopsis

Forty-eight healthy volunteers with a normal sleep/wake history participated in a two-centre, double-blind, parallel group study comparing the effects of estazolam 2.0 mg, triazolam 0.25 mg, and placebo on sleep, performance and alertness following 180 degree reversal in sleeplwake schedule. Sleep-phase reversal produced decreased sleep time, primarily during the last 2 hours of the sleep period. Estazolam prevented this transient insomnia by maintaining sleep in the latter part of the sleep period. Triazolam did not significantly change total sleep time, which was intermediate between that of the estazolam and placebo groups. Neither active compound produced significant effects on subsequent performance or alertness.

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