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Effects of Erwinia-asparaginase on the coagulation system

✍ Scribed by H. Carlsson; D. Stockelberg; L. Tengborn; I. Braide; J. Carneskog; J. Kutti


Book ID
114791983
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
486 KB
Volume
55
Category
Article
ISSN
0902-4441

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## Abstract A randomized study was done in twenty newly diagnosed children with acute lymphoblastic leukemia. Ten children were treated with __Escherichia coli__ L‐asparaginase, and ten with Erwinia chrysanthemi L‐asparaginase. L‐asparaginase (ASP) treatment started halfway during ALL‐induction tre

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Serial coagulation studies were performed in 26 pediatric patients with acute lymphoblastic leukemia during initial induction therapy with vincristine, prednisone, and L-asparaginase. Prolongation of screening coagulation tests was frequent: prothrombin time (in 16 of 26 patients), partial thrombopl