Effects of epidermal growth factor on protein degradation, the translocation of non-histone proteins to the nucleus and DNA synthesis
โ Scribed by Herman Polet; Daniel Fryxell
- Book ID
- 119120971
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 849 KB
- Volume
- 1013
- Category
- Article
- ISSN
- 0167-4889
No coin nor oath required. For personal study only.
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Stimulation of resting transformed cells (Chang liver cells), prelabeled with [3H] leucine, with fetal calf serum, caused increased nuclear translocation of [3H] nonhistone proteins ([3H] NHP) and DNA synthesis and a parallel inhibition of proteolysis of cellular proteins. [3H] NHP migration was ind
Various lysosomotropic amines have two parallel effects in human lymphocytes: they inhibit t h e degradation of cellular proteins and increase the migration of nonhistone proteins (NHP) from the cytoplasm to t h e nucleus. The increased nuclear level of N H P is associated with increased cellular bi