Effects of endotracheally administered distilled water and normal saline on the arterial blood gases of dogs

✍ Scribed by Michael I. Greenberg; Steven I. Baskin; Adele M. Kaplan; Francis J. Urrichio

• Publisher: Elsevier Science
• Year: 1982
• Tongue: English
• Weight: 465 KB
• Volume: 11
• Category: Article
• ISSN: 1097-6760
• DOI: 10.1016/s0196-0644(82)80200-x

✦ Synopsis

The effects of endotracheally (ET) administered distilled water (DW) and normal saline solution (NSS) on the arterial blood gases of clogs were compared. When distilled water was administered endotracheally, arterial pH was depressed to 99.36% of baseline values within 5 minutes. When compared to pH changes following ET administration of NSS the depression of pH following DW administration was significant (P < .05). Following ET injection of DW, arterial P02 was depressed to 61% of baseline values and remained significantly depressed throughout the experiment. In comparison, following ET NSS administration, P02 was depressed substantially less, and remained at significantly higher levels for the entire experiment. In dogs, administration of NSS by the ET route produces less detrimental effects on arterial blood gases than does the ET administration of DW. This may have implications for the choice of diluent for human drug administration using the ET route.