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Effects of elevated expression of the CYP51 (P45014DM) gene on the sterol contents of Saccharomyces cerevisiae

✍ Scribed by Hitoshi Tainaka; Hideaki Hashimoto; Yuri Aoyama; Yuzo Yoshida


Book ID
113397583
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
315 KB
Volume
79
Category
Article
ISSN
0922-338X

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Human and Candida albicans CYP51 were purified to homogeneity after GAL10-based heterologous expression in yeast in order to resolve the basis for the selective inhibition of the fungal enzyme over the human orthologue by the azole drugs ketoconazole and itraconazole, used in the treatment of system