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Effects of edetate on seizure suppressing actions of taurine and GABA

✍ Scribed by Kinji Izumi; Hideki Igisu; Takeo Fukuda

Book ID
118862303
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
249 KB
Volume
88
Category
Article
ISSN
0006-8993

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## Abstract The effect of intraperitoneally injected taurine against the convulsive activity induced by 4‐aminopyridine (4‐AP) was studied in 12‐ to 15‐day‐old mice. At a dose of 2.6 mg/kg, taurine increased the latency of clonic seizures from 7 to 20 minutes, reduced the incidence of tonic seizure

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## Abstract The action of taurine and GABA on the cat cerebral cortex neurons was studied. Electrophoretically administered taurine and GABA hyperpolarized the neuron membrane. GABA, in contrast to taurine, sharply increased the somatic membrane conductance. Taurine action was weaker than that of G