✦ LIBER ✦

Effects of early experience on the metabolism and production of corticosterone in rats

✍ Scribed by Lee J. Grota

Publisher: John Wiley and Sons
Year: 1976
Tongue: English
Weight: 269 KB
Volume: 9
Category: Article
ISSN: 0012-1630
DOI: 10.1002/dev.420090304

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✦ Synopsis

Abstract

Rats were handled for 3 min daily for 3 weeks before or after weaning or were left totally undisturbed. At 80 days of age, animals from each group were selected for corticosterone half‐life determination. Adrenal tissue from the remaining animals was incubated in vitro in the presence or absence of ACTH. Handled and unmanipulated animals did not differ in half‐life or in adrenocortical output. These data do not support the hypothesis that the reduced adrenocortical reactivity that results from manipulating animals is due to either the metabolism of corticosterone or the response of the adrenal cortex to ACTH.

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