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Effects of disulfiram and related compounds on the metabolism in vivo of the colon carcinogen, 1,2-dimethylhydrazine

✍ Scribed by Emerich S. Fiala; George Bobotas; Callie Kulakis; Lee W. Wattenberg; John H. Weisburger

Book ID: 115773633
Publisher: Elsevier Science
Year: 1977
Tongue: English
Weight: 652 KB
Volume: 26
Category: Article
ISSN: 0006-2952
DOI: 10.1016/0006-2952(77)90343-4

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## Abstract 1,2‐dimethylhydrazine (DMH), administered weekly to mice for 20 weeks, induces tumors in the distal segment of colon. Tumors are preceded by enlargement of the mucosal glands resulting from increases in the number of total cells and ^3^H‐thymidine labeled cells/crypt. Cells located in t