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Effects of dimethylsulfoxide on sphingomyelinase activities in normal and Niemann-Pick type A, B and C fibroblasts

โœ Scribed by Satoa Mitsuru; Yoshidaa Yutaka; Sakuragawab Norio; Arimaa Masataka


Book ID
115739953
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
603 KB
Volume
962
Category
Article
ISSN
0005-2760

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โœ M. Masson; B. Spezzatti; J. Chapman; C. Battisti; N. Baumann ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 461 KB

In this report we showed that calmodulin antagonists chlorpromazine (CPZ) and W-7 (N-[6-aminohexyl]-5-chloro-l-naphtalenesulfonamide), when added to fibroblast cell cultures, gave rise to a time-and dosedependent decrease of sphingomyelinase activity. CPZ and W-7 also significantly inhibited LDL-and