Effects of dietary protein and fat on linoleic and α-linolenic acid metabolism and prostacyclin production in stroke-prone spontaneous hypertensive rats
✍ Scribed by Akira Ikeda; Kosaburo Wakamatsu; Takehiro Umeda; Satoko Shikada; Ikuo Ikeda; Katsumi Imaizumi; Michihiro Sugano
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 688 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0955-2863
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✦ Synopsis
The effects of dietary proteins (casein or soybean protein) and fats (perilla oil high in ce-linolenic acid or safflower oil high in linoleic acid) on the fatty acid composition of liver microsomes and the aortic prostacyclin production were studied in stroke-prone spontaneous hypertensive rats. The stimulating effects of casein compared to soybean protein on linoleic acid and ce-linolenic acid metabolism and prostacyclin production were confirmed in this rat model. The ratio of (20:3n-6 + 20:4n-6)/18:2n-6, the linoleic acid desaturation index, of liver microsomes was reflected in that of aorta. In addition, there was a highly positive correlation between the linoleic acid desaturation index of phosphatidylcholine and the prostacyclin production of the aorta. Thus, the results of the present study indicated a significant role of dietary protein in the regulation of polyunsaturated fatty acids and hence, the eicosanoid production. The data showed a possible preferable effect of casein in relation to soybean protein.