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Effects of diclofenac in the rat tail ischaemia–reperfusion injury model of acute hyperalgesia

✍ Scribed by Robert F Grace; Yiguang Lin; Stephen R Edwards; Ian Power; Laurence E Mather

Book ID
117478510
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
137 KB
Volume
89
Category
Article
ISSN
0304-3959

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Aminoguanidine is an inhibitor of nitric oxide synthase (NOS), with high selectivity for the inducible isoform (iNOS). In addition to being an inhibitor of NOS, aminoguanidine also exhibits antioxidant activity. Recent studies suggest that aminoguanidine reduces ischaemia-reperfusion (I/R)-induced d