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Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism

✍ Scribed by Kyung H. Yang; Young H. Choi; Unji Lee; Joo H. Lee; Myung G. Lee


Book ID
111770890
Publisher
Pharmaceutical Press
Year
2009
Tongue
English
Weight
160 KB
Volume
61
Category
Article
ISSN
2042-7158

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Metabolism of Dextromethorphan in vitro:
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Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab