Effects of cytochalasins on developing frog embryos: protection with l-cysteine and ?-d-glucosamine
✍ Scribed by Ghaskadbi, Surendra
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 335 KB
- Volume
- 196
- Category
- Article
- ISSN
- 1432-041X
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✦ Synopsis
Cytochalasins A, B and H (CA, CB and CH)
brought about cellular disaggregation and mortality in the developing embryos of the frog, Microhyla ornata. All three cytochalasins exhibited a dose-response relationship. CA was the most potent and its effects were significantly reduced by simultaneous additon of L-cysteine, a sulph-hydryl compound, e-D-Glucosamine, a precursor of complex macromolecules important in cell adhesion, protected against the effects of CH. The effects of CB, however, were influenced neither by L-cysteine nor by ~-D-glucosamine. The results revealed differences in the mechanism of action of these three cytochalasins.