Effects of Corylus avellana in acetaminophen and CCl4 induced toxicosis

✍ Scribed by M. A. Rusu; N. Bucur; C. Puicǎ; M. Tǎmaş

• Book ID: 101290427
• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 63 KB
• Volume: 13
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199903)13:2<120::aid-ptr403>3.0.co;2-i

✦ Synopsis

Our study investigated the effects of Corylus avellana extract on acetaminophen and carbon tetrachloride intoxicated liver of young rats. Hepatocytolysis was determined by measuring the level of serum transaminases (GPT and GOT), steatosis by Sudan black staining, histological structures by hamatoxylineosin staining and the activity of enzymes such as SDH, GtDH, G-6-Pase and ATPase. Comparatively, the most serious lesions appeared in CCl 4 intoxication. Corylus avellana extract had some beneficial effects in CCl 4 toxicosis: it reduced hepatocytolysis as well as histological lesions and returned the activity of some enzymes to normal values.