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Effects of competitive and noncompetitive NMDA receptor antagonists on kindling and LTP

✍ Scribed by Kiyoshi Morimoto; Kahoru Katayama; Koutaro Inoue; Keiko Sato

Book ID
113224273
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
621 KB
Volume
40
Category
Article
ISSN
0091-3057

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A competitive (NBQX) and a non-competitive (GYKI 52466) AMPA antagonist, and a competitive NMDA antagonist (D-CPPene) were tested against the development of kindling and against fully kindled seizures in amygdala-kindled rats. GYKI 52466, 10 mg/kg given i.p. 5 min prior to electrical stimulation in