Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia
β Scribed by Edward D. Levin; N. Channelle Christopher
- Book ID
- 116840640
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 293 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0278-5846
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## Abstract Rat with excitotoxic neonatal ventral hippocampal lesions (NVHL rats) is considered as a heuristic neurodevelopmental model for studying schizophrenia. Extensive study of this model is limited by the lack of clear validity criteria of such lesions and because ascertaining of the lesions
A neurodevelopmental model of schizophrenia in rats has recently been proposed employing neonatal hippocampal lesions. The present study further characterizes this model by investigating the long-term effects of neonatal hippocampal lesions up to 100 days after birth, in male rats as well as female