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Effects of Ciliary Neurotrophic Factor on Differentiation of Late Retinal Progenitor Cells

✍ Scribed by Tasneem Zahir; Henry Klassen; Michael J. Young


Book ID
111843446
Publisher
AlphaMed Press
Year
2005
Tongue
English
Weight
261 KB
Volume
23
Category
Article
ISSN
1066-5099

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Adenoviral-mediated transfer of ciliary neurotrophic factor (CNTF) to the retina rescued retinal ganglion cells (RGCs) from axotomy-induced apoptosis, presumably via activation of the high affinity CNTF receptor alpha (CNTFRalpha) expressed on RGCs. CNTF can also activate astrocytes, via its low aff